Ficam - Blood Monitoring NOT needed
Obtaining The Right Pest Control Service
|Bayer, manufacturers of the widely-used insecticide Ficam, have released useful information on medical testing requirements following concerns over long-term use of insecticides by pest controllers.|
The active ingredient of Ficam (bendiocarb) is a carbamate whose only known mode of toxic action is by the rapid and direct inhibition of cholinesterase in tissues to which it gains access.
|This inhibition is also rapidly reversed, unlike that produced by most organophosphorous anticholinesterase compounds.|
Clinically effective single oral dosages become ineffective within 2-3 hours. This rapid reversibility of cholinesterase inhibition and rapid breakdown and excretion reduced the likelihood of cumulative anti-cholinesterase effects and eliminates the possibility of accumulation of the active ingredient in mammalian tissues.
This has been confirmed by observations in humans, which have indicated a rapid reversal of cholinesterase inhibition and of clinical symptoms following both acute and sub-acute bendiocarb exposures.
|Thus, in the view of Bayer's experience and knowledge of the toxicology of bendiocarb and products containing it, they are satisfied that there is no scientific justification for blood cholinesterase monitoring during or following use of Ficam products.|
This conclusion is further supported by the following authoritative statements:
|1. WHO/FAO. Data Sheets on Pesticides, No. 52, Bendiocarb (VBCID-S182.52 Rev 1) states in Section 5.2 Surveillance Tests - "Due to the rapid reactivation of inhibited enzyme, determination of blood cholinesterase level is of no value in determining when workers should be withdrawn to prevent over-exposure. Minor complaints, such as headaches and nausea, cause a worker to stop work and thus prevent further exposure. The worker quickly recovers, particularly if appropriate decontamination procedures are followed."|
2. WHO Technical Report Series 634 "Safe use of Pesticides", 1979, states on page 18 "No cholinesterase monitoring is indicated when carbamate insecticides are applied because the inhibited enzyme reactivates rapidly, causing marked symptom-less daily fluctuation in cholinesterase activity, thus rendering the monitoring of little practical value".
3. Vandekar, M., Resid. Rev., 1980, 75 67 states on page 74 "No cholinesterase monitoring is indicated when carbamate insecticides are applied since the inhibited enzyme reactivates too rapidly for this to be of any value in preventing overexposure."
The American Environmental Protection Agency have also issued a release, extracted from EPA R.E.D FACTS for Bendiocarb - Human Health Assessment Toxicity."
It states that: "Bendiocarb is classified as a "Group E" chemical, showing no evidence of carcinogenicity in laboratory animals or in humans. Developmental and reproductive toxicity studies did not show evidence of increased susceptibility of rat or rabbit fetuses following in utero exposure or in offspring following pre- and/or post-natal exposure. There was no evidence of mutagenicity following in vivo or in vitro exposure to bendiocarb. Metabolism studies conducted with rats, mice, hamsters, dogs and humans all indicate that bendiocarb is rapidly absorbed following oral exposure and the majority of the administered dose is eliminated in the urine."
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